That would be my suggestion as well.
Well… the suggested layout remains multiple mirror VDEVs, or at the very least multiple VDEVs… you could experiment with 2x 4-wide RAIDZ1 VDEVs.
I suggest reading this and this.
Ultimately, it depends on your hardware and your use case: not all silicon is born equal.
You can also consider dedicating a single mirror VDEV to iSCSI and using the remaining 6 in RAIDZ1 (or 2) fo more traditional protocols.