If I had to guess you’re impacted by:
USB attached SATA disks may use the same serial number, confusing software that attempts to detect multipathed disks.
Edit:
// If sata ports are unavailable or limited on the machine I’d strongly recommend getting a cheap LSI HBA with firmware flashed to IT mode for ~$30 USB on ebay instead of continuing to try getting USB HDDs working. You’ll save yourself a lot of time & lost data.
I also can’t find that specific model of OptiPlex, but I’m hoping you got at least 1 free Pcie slot available somewhere in there. Don’t forget to slap a fan in pointing at the HBA.