New build, new to truenas

I need some guidance on how I should build my nas configuration. I’ve been reading the forums and I have some ideas I just want to know people’s takes on what’s the best approach.

I’m converting an old dell workstation
Xeon 1620v3
16/32gb ram
Lsi 9207/9300 not sure which one - prices are close
16i or is 8i fine for this build.

I’ll be building this in a nas case that supports 12x 3.5 and 5x 2.5(ssd) might be able to fit a 6th

Run 2 raidz1 x 6(12 disks) in mirror or 12x raidz2. This is mainly for files for (vms, movies, personal files)
Run 2 raidz1 x 2(4drives) in mirror for vms this limits space but I like the redundancy it offers with performance or does it not matter on ssds?
Run 2 drives in mirror for boot.

Questions what’s the real performance hit of running in raidz2?

“Raidz1 in mirror” makes no sense.

VMs should be on mirrors, preferably SSDs, for efficiency with small blocks.
General, and large, files for NFS/SMB shares can be on raidz arrays, preferably raidz2 for safety and resiliency.

Xeon 1620v3
This should have sveral PCIe slots with bifurcation, so many opportunities for NVMe drives in place of or in addition to SATA SSDs.

Why? Is the NAS in a remote, hard to access, place?

9300-16i is basically 2x8i together with a switch. Double the power and electricity and will run hot.

Get 9300-8i, 9305-16i or 9207