Right, what about the Helium/Air factor?
And what would be a good reliable backup strategy without using the Cloud?
Having irreplaceable memories on a NAS would mean that that the NAS needs to be secured properly. I don’t really care about accessing it directly via reverse proxy. I would rather just VPN into my Network and access it there if I had to.
As much as I would like to Isolate it from the Internet, I would like it to be able to pull Updates/install new Containers.
Any advice would be appreciated. Thanks.
You can follow the often recommended 3-2-1 strategy:
3 copies of the data
2 different storage media
1 copy off-site or as I see it at least on a seperate machine (if you can live with the risk of a disaster that destroys everything)
For remote access I use Tailscale, and it works very well.
I’ve had a series of bad luck with Seagate for a period of 3-5 years, so I tend to stay away from them. HGST was what I was primarily using before they got purchased by WD, so now I mainly use WD drives with Helios tech (helium filled drives).
If offsite, what would be an ideal way to have that much data and yet add strong encryption to it incase it falls into the wrong hands?
Are there any WD Red Drives with Helium if its worth it? Not looking at Enterprise Drives due to the noise as its for a Home stored away.
From and older thread - WD Reds SMART ID 22 "Helium Level"? | TrueNAS Community
Seems like helium filled is common in Enterprise class drives & can be identified via if it has a breather hole or not. My 120mm, 140mm high static cooling fans produce way more noise than the hdds, so I’ve never really thought about the drive noise. 
Wrong concerns on all counts: I don’t think there are non-helium drives in the capacities you’re looking at, and enterprise drives are build on the same hardware plateforms as the consumer lines—similar noise and power.
never used it personally but it documented - Setting Up a Remote Replication Task | TrueNAS Documentation Hub - there a checkbox for encryption.
Seems to be people saying dont buy WD and don’t buy Seagate. Does it depend on someones luck?
I know someone who has had Seagates in their NAS for 5 years and had no issues.
The plural of anecdote is not data.
Both manufacturers generally make decent drives, and both of them ship the occasional dud. Each of them has also made the occasional misstep–Seagate had a series of drives, many years back, that were catastrophically bad; WD did the whole SMR thing. Pick your poison.
Yes, plus the phase of the Moon and whether Mercury is in Aquarius. 
Otherwise, you still have Toshiba.
How is Seagate now?
Ironwolf Pro drives are solid from my recent experience. But do burn ins anyway.
Most NAS or enterprise grade drives are fine. I prefer WD/HGST SAS3 drives. Industry wide, they have the lowest failure rates.
ALWAYS do burn in testing before committing any drive to service.
I have been using “used” enterprise drives for nearly 25 years. From IDE, to SCSI, SATA, SAS3. Spinning rust, SSD or NVME. In that time, I have experienced very few failures that actually put my data at risk. I have never had to do a full data restore from backup because of a single or even one instance of a double drive failure.
Anyway, welcome to the TrueNAS community. You are in the right place. 
How did you find out my investing strategy? 
There are the Backblaze drive reporting statistics, which are harvested SMART readings and annualised failure rates:
How can this be done?
Anecdotesies?
If I got my hands on the 12TB Seagate 3.5" 7200rpm SATA IronWolf Pro HDD ST12000NT001, should I return it for a WD? I’m thinking if it really worth it at the end of the day…
Looked at WD Ultrastar and its quite expensive for my needs.