Gone for the weekend, returned to pool missing, possible drive failure, no idea what to do

Server grade hardware might help. LSI (Broadcom) HBA these need good cooling. Server chassis usually set up good, but noisy.

Replicating you data pool to another ZFS machine or other backup can help with this type of weird failure. Not sure if the reason was ever figured out.

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Hardware guide can be downloaded as a PDF, see yellow download button on upper right

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